What is Novocart® Disc?

NOVOCART® DISC is a high-quality autologous cell compound in an innovative hydrogel for the biological reconstruction of partially damaged discs following disc prolapse.
The product’s main features are:

• High vitality
• Individually manufactured for each patient
• Capable of synthesizing the important matrix components collagen Type-II and aggrecan
• Capable of synthesizing important growth and differentiation factors
• Exclusion of over-expression of dedifferentiation markers (collagen Type-I) and of cartilage-destructive inflammation mediators such as Interleukin-1ß
• Use of GMP-compliant manufactured homologous serum
• Use of a high-quality in situ polymerizable hydrogel, subjected to a validated quality control dependent on load
• No antibiotics or antimycotics

Biological disc reconstruction
The only procedure allowing for biological reconstruction of partially damaged disc tissue before massive degeneration occurs is the transplantation of in vitro cultivated chondrocytes from autologous disc tissue,or ADCT (Autologous Disc Cell Transplantation). ADCT is comparable to joint ACT (Autologous Chondrocyte Transplantation) in its biological mode of action and in its biotechnological aspects. In both cases, isolated from the biopsy material, the cultivated cartilage cells induced the desired reconstruction. One further special feature of NOVOCART® DISC is the hydrogel used, which fixes the cells in the damaged disc, and possesses a range of other important properties, such as being anti-inflammatory.

Description of ADCT with NOVOCART® DISC
Transplantation of the cultivated disc cells can take place three months after extraction by way of operation of the prolapsed disc. The relatively long period between tissue extraction and cell transplantation must be adhered to, to ensure that the protective fiber ring (annulus fibrosus) is fully healed following the intervention.