Ärzteinformation
Erfahren Sie mehr über die Fortschritte bei der Knorpelreparatur mit MACT. Greifen Sie auf mehr als 20 Studien zu, sehen Sie sich Videos zu Operationstechniken an und laden Sie medizinische Informationen und Patienteninformationen herunter.
.webp)
Publikationen
MACT
2024
Weishorn J, Wiegand J, Zietzschmann S, Koch KA, Rehnitz C, Renkawitz T, Walker T, Bangert Y.
Factors Influencing Long-term Outcomes After Matrix-Induced Autologous Chondrocyte Implantation: Long-term Results at 10 Years. American Journal of Sports Medicine. 2024 Sep; 52(11): 2782-2791. DOI: 10.1177/03635465241270152.
2024
Eichinger M, Henninger B, Petry B, Schuster P, Herbst E, Wagner M, Rosenberger R, Mayr R.
Treatment of cartilage defects in the patellofemoral joint with matrix-associated autologous chondrocyte implantation effectively improves pain, function, and radiological outcomes after 5-7 years. Archive of Orthopaedic Trauma Surgery. 2024 Apr; 144(4): 1655-1665. DOI: 10.1007/s00402-023-05179-0.
2023
Snow M, Mandalia V, Custers R, Emans PJ, Kon E, Niemeyer P, Verdonk R, Gaissmaier C, Roeder A, Weinand S, Zöllner Y, Schubert T.
Cost-effectiveness of a new ACI technique for the treatment of articular cartilage defects of the knee compared to regularly used
ACI technique and microfracture. Journal of Medical Economics. 2023 Apr; 26: 1,537-546. DOI: 10.1080/13696998.2023.2194805.
2022
Angele P, Zellner J, Schröter S, Flechtenmacher J, Fritz J, Niemeyer P.
Biological Reconstruction of Localized Full-Thickness Cartilage Defects of the Knee: A Systematic Review of Level 1 Studies with a Minimum Follow-Up of 5 Years. Cartilage. 2022 Dec; 13(4): 5-18. DOI: 10.1177/19476035221129571.
2016
Bretschneider H, Stiehler M, Hartmann A, Boger E, Osswald C, Mollenhauer J, Gaissmaier C, Günther K-P
Characterization of primary chondrocytes harvested from hips with femoroacetabular impingement. Osteoarthritis Cartilage. 2016 Sep; 24(9): 1622-8. DOI: 10.1016/j.joca.2016.04.011.
2016
Niemeyer P, Albrecht D, Andereya S, Angele P, et al.
Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU).The Knee. 2016 Jun; 3: 426-435. DOI: 10.1016/j.knee.2016.02.001.
MACT with a Collagen Matrix
2025
Lenz JE, Weber J, Zellner J, Zimmermann G, Müller PE, Barié A, Popp D, Ostermeier S; Krackhardt T, Mehl J, Alt V, Angele P.
A non‐interventional study to evaluate the safety and effectiveness of abiphasic, chondrocyte‐containing biomaterial (NOVOCART® 3D) in the treatment oflocalized full‐thickness cartilage defects or osteochondral lesions of the kneejoint (NISANIK). Journal of Experimental Orthopaedics. 2025 Aug; 12(3): e70346. DOI: 10.1002/jeo2.70346.
2025
Janacova V, Szomolanyi P, Sitarcikova D, Kirner A, Trattnig S, Juras V.
Texture Analysis of Cartilage Repair Tissue Maturation: Comparison of Two Cartilage Repair Methods and Correlation with MOCART 2.0., 2025 Jan; 1-19. DOI: 10.1177/19476035241313047.
2024
Weishorn J, Koch K-A, Zietzschmann S, Trefzer R, Walker T, Renkawitz T, Bangert Y.
Neutral to slightly undercorrected mechanical leg alignment provides superior long‐term results inpatients undergoing matrix‐associated autologous chondrocyte
Implantation.Knee Surgery Sports Traumatology Arthroscopy. 2024 May; 32(8): 2040-2051. DOI: 10.1002/ksa.12226.
2024
Eichinger M, Henninger B, Petry B, Schuster P, Herbst E, Wagner M.
Treatment of cartilage defects in the patellofemoral joint with matrix‑associated autologous chondrocyte implantation effectively improves pain, function, and radiological outcomes after 5–7 years. Orthopaedic and Trauma Surgery. 2024 Sep; 144: 1655-166. DOI: 10.1007/s00402-023-05179-0.
2022
Ehmann YJ, Zuche L, Schmitt A, Berthold DP, Rupp MC, Muench LN, Otto A, Woertler K, Imhoff AB, Mehl J.
Excellent clinical and radiological outcomes after both open flake refixation and autologous chondrocyte implantation following acute patella dislocation and concomitant flake fractures. Knee Surgery, Sports Traumatology, Arthroscopy. 2022 Feb. DOI: 10.1007/s00167-022-06899-3.
2021
Juras V, Szomolanyi P, Janáčová V, Kirner A, Angele P, Trattnig S.
Differentiation of Cartilage Repair Techniques Using Texture Analysis from T2 Maps. Cartilage. 2021 Dec; 13 (1_suppl): 718S-728S. DOI: 10.1177/19476035211029698.
2021
Angele P, Docheva D, Pattappa G, Zellner J.
Cell-based treatment options facilitate regeneration of cartilage, ligaments and meniscus in demanding conditions of the knee by a whole joint approach. Knee Surgery, Sports Traumatology, Arthroscopy. 2021 Mar. DOI: 10.1007/s00167-021-06497-9.
2021
Niethammer TR, Gallik D, Chevalier Y, Holzgruber M, Baur-Melnyk A, Müller PE, Pietschmann MF.
Effect of the defect localization and size on the success of third-generation autologous chondrocyte implantation in the knee joint. International Orthopaedics. 2021 Jun; 45(6): 1483-1491. DOI: 10.1007/s00264-020-04884-4.
2021
Niethammer TR, Altmann D, Holzgruber M, Goller S, Fischer A, Müller PE.
Third generation autologous chondrocyte implantation is a good treatment option for athletic persons. Knee Surgery, Sports Traumatology Arthroscopy. 2021 Apr; 29(4): 1215-1223. DOI: 10.1007/s00167-020-06148-5.
2020
Gersing AS, Holwein C, Suchowierski J, Feuerriegel G, Gassert FT, Baum T, Karampinos DC, Schwaiger BJ, Makowski MR, Woertler K, Imhoff AB, Jungmann PM.
Cartilage T2 Relaxation Times and Subchondral Trabecular Bone Parameters Predict Morphological Outcome After Matrix-Associated Autologous Chondrocyte Implantation With Autologous Bone Grafting.The American Journal of Sports Medicine. 2020 Nov; 48(14): 3573–3585. DOI: 10.1177/0363546520965987.
2020
Niethammer TR, Altmann D, Holzgruber M, Gülecyüz MF, Notohamiprodjo S, Baur-Melnyk A, Müller PE.
Patient-Reported and Magnetic Resonance Imaging Outcomes of Third-Generation Autologous Chondrocyte Implantation After 10 Years. Arthroscopy. 2020 Jul; 36(7): 1928-1938. DOI: 10.1016/j.arthro.2020.03.009.
2020
Gersing AS, Feuerriegel G, Holwein C et al.
T2-relaxation time of cartilage repair tissue is associated with bone remodeling after spongiosa-augmented matrix-associated autologous chondrocyte implantation. Osteoarthritis Cartilage. 2019 Jan; 27(1): 90-98. DOI: 10.1016/j.joca.2018.08.023.
2020
Niethammer TR, Gallik D, Chevalier Y et al.
Effect of the defect localization and size on the success of third-generation autologous chondrocyte implantation in the knee joint. International Orthopaedics.2021 Jun; 45(6): 1483-1491. Epub 2020 Dec. DOI: 10.1007/s00264-020-04884-4.
2017
Zellner J, Grechenig S, Pfeifer CG, Krutsch W, Koch M, Welsch G, Scherl M, Seitz J, Zeman F, Nerlich M, Angele P.
Clinical and Radiological Regeneration of Large and Deep Osteochondral Defects of the Knee by Bone Augmentation Combined With Matrix-Guided Autologous Chondrocyte Transplantation. American Journal of Sports Medicine. 2017 Nov; 45(13): 3069-3080. DOI: 10.1177/0363546517717679.
2017
Niethammer TR, Holzgruber M, Gülecyüz MF, Weber P, Pietschmann MF, Müller PE.
Matrix based autologous chondrocyte implantation in children and adolescents: a match paired analysis in a follow-up over three years post-operation. International Orthopaedics. 2017 Feb; 41(2): 343-350. DOI: 10.1007/s00264-016-3321-1.
2016
Niethammer TR, Limbrunner K, Betz OB, Gülecyüz MF, Pietschmann MF, Feist M, Müller PE.
Analysis of the autologous chondrocyte quality of matrix-based autologous chondrocyte implantation in the knee joint. International Orthopaedics. 2016 Jan; 40(1): 205-12. DOI: 10.1007/s00264-015-2825-4.
2015
Dell'Osso G, Ghilardi M, Bottai V, Bugelli G, Guido G, Giannotti S.
Up-to-date Review and Cases Report on Chondral Defects of Knee Treated by ACI Technique: Clinical-instrumental and Histological Results. Surgical Technology International. 2015 May; 26: 317-23. PMID:26055026.
2014
Niethammer TR, Safi E, Ficklscherer A, Horng A, Feist M, Feist-Pagenstert I, Jansson V, Pietschmann MF, Müller PE.
Graft maturation of autologous chondrocyte implantation: magnetic resonance investigation with T2 mapping. American Journal of Sports Medicine. 2014 Sep; 42(9): 2199-204. DOI: 10.1177/0363546514538756.
2014
Zak L, Albrecht C, Wondrasch B, Widhalm H, Vekszler G, Trattnig S, Marlovits S, Aldrian S.
Results 2 Years After Matrix-Associated Autologous Chondrocyte Transplantation Using the Novocart(R) 3D Scaffold: An Analysis of Clinical and Radiological Data. American Journal of Sports Medicine. 2014 Jul; 42(7): 1618-27. DOI: 10.1177/0363546514532337.
2013
Zellner J, Angele P, Zeman F, Kujat R, Nerlich M
Is the transplant quality at the time of surgery adequate for matrix-guided autologous cartilage transplantation? A pilot study. Clinical Orthopaedics and Related Research. 2013 Sep; 471(9): 2852-61. DOI: 10.1007/s11999-013-2958-y.
2012
Pietschmann MF, Niethammer TR, Horng A, Gülecyüz MF, Feist-Pagenstert I, Jansson V, Müller PE.
The incidence and clinical relevance of graft hypertrophy after matrix-based autologous chondrocyte implantation. American Journal of Sports Medicine. 2012 Jan; 40(1): 68-74. DOI: 10.1177/0363546511424396.
2011
Ochs BG, Müller-Horvat C, Albrecht D, Schewe B, Weise K, Aicher WK, Rolauffs B.
Remodeling of articular cartilage and subchondral bone after bone grafting and matrix-associated autologous chondrocyte implantation for osteochondritis dissecans of the knee. American Journal of Sports Medicine. 2011 Apr; 39(4): 764-73. DOI: 10.1177/0363546510388896.
2011
Nuernberger S, Cyran N, Albrecht C, Redl H, Vécsei V, Marlovits S.
The influence of scaffold architecture on chondrocyte distribution and behavior in matrix-associated chondrocyte transplantation grafts. Biomaterials. 2011 Feb; 32(4): 1032-40. DOI: 10.1016/j.biomaterials.2010.08.100.
MACT with a Hydrogel
2024
Bumberger A, Niemeyer P, Angele P, Wright EK, Faber SO.
Hydrogel-based and spheroid-basedautologous chondrocyte implantation of the knee show similar 2-year functional outcomes: An analysis based on the German Cartilage Registry (Knorpel Register DGOU). Knee Surgery Sports Traumatology Arthroscopy. 2024 May; 32(9): 2258-2266. DOI: 10.1002/ksa.12248.
2024
Gaissmaier C, Angele P, Spiro RC, Köhler A, Kirner A, Niemeyer P.
Hydrogel-BasedMatrix-Associated Autologous Chondrocyte Implantation Shows Greater Substantial Clinical Benefit at 24 Months Follow-Up than Microfracture: A Propensity Score Matched-Pair Analysis. Orthopaedic Surgeon of Sports Medicine. 2024 Aug; DOI: 10.1177/19476035241235928.
2023
Niemeyer P, Angele P, Spiro RC, Kirner A, Gaissmaier C.
Comparison of Hydrogel-Based Autologous Chondrocyte Implantation Versus Microfracture: A Propensity Score Matched-Pair Analysis.Orthopaedics Journal of Sports Medicine. 2023 Aug; 11(8): 23259671231193325. DOI: 10.1177/23259671231193325.
2023
Riedl M, Bretschneider H, Dienst M, Günther KP, Landgraeber S, Schröder J, Trattnig S, Fickert S.
Two-Year Results of Injectable Matrix-Associated Autologous Chondrocyte Transplantation in the Hip Joint: Significant Improvement in Clinical and Radiological Assessment. Journal of Clinical Medicine. 2023 Aug; 23; 12(17): 5468. DOI: 10.3390/jcm12175468.
2022
Janacova V, Szomolanyi P, Kirner A, Trattnig S, Juras V.
Adjacent cartilage tissue structure after successful transplantation: a quantitative MRI study using T2 mapping and texture analysis. European Radiology. 2022 Jun; 32(12): 8364-8375. DOI: 10.1007/s00330-022-08897-y.
2022
Niethammer TR, Uhlemann F, Zhang A, Holzgruber M, Wagner F, Müller PE.
Hydrogel‑based autologous chondrocyte implantation leads to subjective improvement levels comparable to scaffold based autologous chondrocyte implantation. Knee Surgery Sports Traumatology Arthroscopy. 2022 Feb; 30: 3386–3392. DOI: 10.1007/s00167-022-06886-8.
2022
Niemeyer P, Hanus M, Belickas J, László T, Gudas R, Fiodorovas M, Cebatorius A, Pastucha M, Hoza P, Magos K, Izadpanah K, Paša L, Vásárhelyi G, Sisák K, Mohyla M, Farkas C, Kessler O, Kybal S, Spiro B, Köhler A, Kirner A, Trattnig S, Gaissmaier C.
Treatment of Large Cartilage Defects in the Knee by Hydrogel-Based Autologous Chondrocyte Implantation: Two-Year Results of a Prospective, Multicenter, Single-Arm Phase III Trial. 2022 Jan-Mar; 13(1). DOI: 10.1177/19476035221085146.
2021
Blanke F, Oehler N, Haenle M, Lenz R, Vogt S, Tischer T.
All-Arthroscopic Hydrogel-Based Autologous Chondrocyte Transplantation in the Knee Joint: Good Clinical and Magnetic Resonance Imaging Outcome After 24 Months. Arthroscopy. 2021 Jun; 37(6): 1892-1899. DOI: 10.1016/j.arthro.2021.01.038.
2020
Schlumberger M, Schuster P, Bulow HJ, et al.
[Technique of all arthroscopic autologous chondrocyte implantation (ACI) for the treatment of cartilage defects in the knee]. Operative Orthopädie und Traumatologie. 2020 Dec; 32(6): 532-544. DOI: 10.1007/s00064-020-00657-9.
2020
Bretschneider H, Trattnig S, Landgraeber S, Hartmann A, Günther KP, Dienst M, Schröder J, Fickert S.
Arthroscopic matrix-associated, injectable autologous chondrocyte transplantation of the hip: significant improvement in patient-related outcome and good transplant quality in MRI assessment. Knee Surgery, Sports Traumatology, Arthroscopy. 2020 Apr; 28(4): 1317-1324. DOI: 10.1007/s00167-019-05466-7.
2019
Bretschneider H, Trattnig S, Landgraeber S, Hartmann A, Günther K-P, Dienst M, Schröder J, Fickert S.
Arthroscopic matrix-associated, injectable autologous chondrocyte transplantation of the hip: significant improvement in patient-related outcome and good transplant quality in MRI assessment. Knee surgery, Sportstraumatology, Arthroscopy: official journal of the ESSKA. 2019 Apr. DOI: 10.1007/s00167-019-05466-7.
2019
Schlumberger M, Schuster P, Bülow HJ, Mayer P, Eichinger M, Richter J.
Arthroscopic autologous chondrocyte implantation in the knee with an in situ crosslinking matrix: minimum 4-year clinical results of 15 cases and 1 histological evaluation. Archives of Orthopaedics and Trauma Surgery. 2019 Nov; 139(11): 1607-1615. DOI: 10.1007/s00402-019-03243-2.
2018
Thier S, Baumann F, Weiss C, Fickert S.
Feasibility of arthroscopic autologous chondrocyte implantation in the hip using an injectable hydrogel. HIP International. 2018 Jul; 28(4): 442-449. DOI: 10.5301/hipint.5000580.
Niemeyer P, Hanus M, Belickas J, László T, Gudas R, Fiodorovas M, Cebatorius A, Pastucha M, Hoza P, Magos K, Izadpanah K, Paša L, Vásárhelyi G, Sisák K, Mohyla M, Farkas C, Kessler O, Kybal S, Spiro R, Köhler A, Kirner A, Trattnig S, Gaissmaier C.
Treatment of Large Cartilage Defects in the Kneeby Hydrogel-Based Autologous Chondrocyte Implantation: A 5-Year Follow-Up of a Prospective, Multicenter, Single-Arm Phase III Trial. Cartilage. 2025; 0(0). DOI: 10.1177/19476035251334737.
Niethammer TR, Uhlemann F, Zhang A, Holzgruber M, Wagner F, Müller PE.
Hydrogel-based autologous chondrocyte implantation leads to subjective improvement levels comparable to scaffold based autologous chondrocyte implantation. Knee Surgery, Sports Traumatology, Arthroscopy: official journal of the ESSKA. 2022 Febr; 30: 3386–3392. DOI: 10.1007/s00167-022-06886-8.
Thier S, Weiss C, Fickert S.
Arthroscopic autologous chondrocyte implantation in the hip for the treatment of full-thickness cartilage defects - A case series of 29 patients and review of the literature. SICOT Journal.2017 Dec; 3: 72. DOI: 10.1051/sicotj/2017037.
Videos
Die folgenden Videoclips enthalten Informationen zu NOVOCART® 3D (kollagenbasierte Knorpelzelltransplantation) und NOVOCART® Inject (gelbasierte Knorpelzelltransplantation). Bitte entnehmen Sie Details zur Anwendung, zu Risiken und Nebenwirkungen den unten stehenden Dokumenten.
06:35 min
07:30 min
06:49 min
08:22 min
02:33 min