Innovation at a Cellular Level
Founded in Reutlingen, Germany, TETEC AG has over 20 years of experience developing cell-based knee cartilage repair therapies. We provide two approaches using the patient's own cells: Injectable MACT (Matrix-Associated Autologous Chondrocyte Transplantation) and MACT, with 30,000 patient-specific therapies to date [1].
Now part of Octane Medical Group—a global organisation specialising in advanced bioprocessing and automation—we continue to advance manufacturing and biomaterials for next-generation cartilage regeneration.
Source: TETEC AG
Setting a New Standard
Today, preparing a patient’s cells for implantation involves a lengthy process—from biopsy to implant preparation. Following a biopsy, the cartilage cylinders are transported to our facility, where the cartilage-bone cylinders are expanded and handled under controlled conditions. Only when they meet all quality requirements are they returned to the surgeon for implantation.
Together with Octane, we’re working to make regenerative medicine the new standard of care. Combining decades of clinical expertise with automated cell manufacturing technologies, we aim to shape a future in which cell expansion happens closer to the patient—preserving quality and streamlining care.
Powering Tomorrow’s Care
Central to our vision is the planned integration of the Octane Cocoon bioreactor under Good Manufacturing Process (GMP)—a closed, automated system built for cell-therapy manufacturing. Learn more about Cocoon and how it could help bring cartilage regeneration to the point of care.
Knee Cartilage Repair With Cells
TETEC provides two cell-based approaches for knee cartilage repair: Injectable MACT and MACT.
Injectable MACT Procedure
Injectable MACT is a cell-based cartilage-repair procedure in which a patient's own cartilage cells are combined with a hydrogel and implanted into a focal knee cartilage defect. [2] In clinical studies and earlier publications, this approach is also described as hydrogel-based ACI or injectable MACI.
- Injectable hydrogel containing the patient’s cartilage cells
- Implanted arthroscopically through small incisions
- Available as outpatient or inpatient care, as appropriate
MACT Procedure
In MACT, the patient's own cells are placed on a collagen scaffold and implanted for the treatment of focal knee cartilage defects [3].
- Patch-like scaffold seeded with the patient’s cartilage cells
- Implanted through a standard surgical incision
- Available as outpatient or inpatient care, as appropriate
From Discovery to Therapy
TETEC research combines expertise in cell biology, biomedical engineering, materials science, and clinical orthopaedics. Collaborating with academic, clinical, and industry partners, our teams investigate new biomaterials, optimise cell culture methods, and translate and scale laboratory findings into viable therapies—while upholding strict safety, quality, and regulatory standards under Good Manufacturing Practice (GMP).
Our Leadership
With decades of experience in science, medicine, and business, our leadership team includes members recognised by leading scientific and medical organisations.
Recognition and Collaboration
TETEC is engaged with leading academic, clinical, and industry collaborators to advance research and therapy development.
Honoured by the Scientific Community
United Through Collaboration
TETEC Locations
Our facilities possess robust manufacturing capability to meet demand.
Designed for Precision
Located near Stuttgart Airport, our Reutlingen facility includes modern cleanrooms, specialised tissue engineering environments, and advanced cell culture laboratories. Together with Octane, we are developing Reutlingen into a centre of excellence for cartilage regeneration, with capacity for high-throughput production. Learn more about our facility and the precision-driven processes that ensure consistent quality under Good Manufacturing Practice (GMP).
Regulatory Standards and Compliance
Cell therapies are manufactured under strict European regulatory frameworks, with processes designed to uphold safety, integrity, and full traceability.
Join Our Growing Team
We need dedicated people to join our 130+ member team, where experts in cell and molecular biology, clinical medicine, and pharmacology work side by side. Opportunities include research and development, quality control, production, and logistics. With a flexible structure that supports career growth, you can help shape the therapeutic solutions of tomorrow to improve patients’ health and quality of life.
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I value taking on responsibility and actively driving change. Working together with the different teams makes this role especially exciting.”
Larissa Bocks
Larissa Bocks
I am motivated by improving processes and tackling challenges within interdisciplinary teams. As a relatively small and diverse company with flat hierarchies, decision-making processes can be carried out quickly.”
Katharina Reinhardt Heller
Katharina Reinhardt Heller
TETEC AG is also a wonderful employer for career starters, offering a great first step from the university environment into industry. The helpfulness of the colleagues turns an applicant into a fully valued team member.”
Raphael Parusel
Raphael Parusel
2025-01-02
TETEC AG’S CDMO business is now Octane CDMO, a global operation with automation expertise
Kingston, Ontario, January 2, 2025 – The Octane Medical Group is pleased to announce that the contract development and manufacturing arm of its German subsidiary TETEC AG...
2024-06-11
Octane Medical acquires B. Braun’s global orthobiologics business
Kingston, Ontario, Canada / Melsungen, Germany, June 5th, 2024 – Octane Medical Group...
2023-12-18
Application for central authorisation submitted to the EMA
TETEC AG has submitted an application for centralized approval of a gel-based matrix-associated cartilage cell product as an advanced...
Connect with TETEC
Conferences
Connect with TETEC at upcoming MACT congresses and events
12.-13. Februar 2026
4. Kongress Patella Femoral der DKG - Berlin
13.-14. März 2026
AGA Advanced Kurs - Patellofemorale Chirurgie in Köln
19.-21. März 2026
7. Münchner Kurs Sportorthopädie | DKG Modulkurs 1
23.-26. März 2026
Orthopaedic Filmfestival 2026 | digital
Contact TETEC
Do you need more information about us, our products, the MACT procedure or our user training?
1. Data on File. TETEC AG. Internal registry and reporting of Injectable MACT and MACT procedures performed in Germany. Reutlingen (DE): TETEC AG; 2025.
2. TETEC AG. Fachinformation NOVOCART Inject. Reutlingen (DE): TETEC AG; 2022. Stand der Information: 12/2022. PEI.A.11763.01.1.
3. TETEC AG. Fachinformation NOVOCART 3D. Reutlingen (DE): TETEC AG; 2023. Stand der Information: 11/2023. PEI.A.11511.01.1.